Cerebrospinal Fluid Biomarker Candidates for Parkinsonian Disorders
نویسندگان
چکیده
منابع مشابه
Cerebrospinal Fluid Biomarker Candidates for Parkinsonian Disorders
The Parkinsonian disorders are a large group of neurodegenerative diseases including idiopathic Parkinson's disease (PD) and atypical Parkinsonian disorders (APD), such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The etiology of these disorders is not known although it is considered to be a combination of genetic and envi...
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Background: Cerebrospinal fluid (CSF) is in close contact with the extracellular fluid surrounding brain cells and therefore holds great promise as a source of biomarkers for Parkinson’s disease (PD). PD biomarkers could improve the early diagnostic accuracy of PD, may be used to identify patients at risk of developing PD, stratify patients into subtypes and monitor disease progression. The cur...
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PURPOSE Dysfunctional proteostasis, with decreased protein degradation and an accumulation of ubiquitin into aggregated protein inclusions, is a feature of neurodegenerative diseases. Identifying new potential biomarkers in cerebrospinal fluid (CSF) reflecting this process could contribute important information on pathophysiology. EXPERIMENTAL DESIGN A developed method combining SPE and PRM-M...
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BACKGROUND Clinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive diagnosis is only possible post-mortem. OBJECTIVE Since impaired protein degradation plays an important role in many neurodegenerative disorder...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2013
ISSN: 1664-2295
DOI: 10.3389/fneur.2012.00187